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Systems Biology and Cellular Compartmentalization
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Role of protein fatty acylation in metabolic regulation, apoptosis and cancer
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Mechanisms of nerve growth and regeneration
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Evolutionary Cell Biology: the membrane-trafficking system and Golgi apparatus
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Project I. Mechanism of membrane fusion using a yeast vacuole model system
Project II. Rac signal transduction and control of secretion in inflammatory cells
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Analysis of mechanisms for integration of cell function within tissues
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Mitochondrial biogenesis and function in health and disease
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Project I. Dynamics of RNA interference effector complexes.
Project II. Non-structural functions of virus capsid proteins
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A genetic model for Neurofibromatosis Type II: Identification and characterization of protein partners of the Merlin tumour suppressor protein
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Molecular mechanism of action of the Hsp90 chaperone
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Regulation of cellular triacylglycerol and cholesterol metabolism
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Regulation of protein traffic to and through the Golgi complex
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Investigating mRNA export and its role in the eukaryotic gene expression program
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Spinal Cord Injury and Rehabilitation Engineering/Neuroscience
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Regulation of cell-cell adhesion in epithelial cells
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The genetic regulation of developmental decisions in C. elegans
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Molecular Mechanisms of Peroxisome Biogenesis and Prion Formation
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Mechanisms governing endoplasmic reticulum homeostasis and apoptosis
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1. Regulation and trafficking of mRNA molecules
2. Cardiac muscle differentiation
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Molecular dynamics of transport through the nuclear pore complex